A military weapons manufacturer creates a chemical weapon that causes victims to become blood-lusting killers. A lab accident causes the building to go into lock-down and the employees are trapped inside with the crazed killers.

The porn star Moon spends her time working, nursing her widowed father that has Parkinson disease and with her friends Jessie and Martine. Her boss Aronson gives a new contract to Moon to be signed. Moon has a blind date with Jessie's friend Kip and they feel a great attraction for each other. When Jessie asks Moon to test the fidelity of her boy-friend, Moon decides to offer the service to other customers. But when she meets the dangerous Terry, she reevaluates her life and her relationship with Skip.

"Wealthy college student Richard Sachs arranges a web broadcast contest originating from a local haunted house. He entices three young couples to spend Halloween night in the abandoned dwelling by offering $5,000 in prize money. The last owner of the house was deranged killer Sean McIntyre, who murdered his entire family 20 years prior on Thanksgiving Day before hanging himself. McIntyre was an amateur mountain climber who used his grappling hook to gruesome effect during his murder spree; we learn that his descent into madness began when he killed what he believed was a Yeti on a trek up the Himalayas. "Richard has mini-video cameras situated throughout the McIntyre house to capture the happenings for his Internet broadcast," O'Hara continues. "When subscriptions for the show lag, he hires a porn star to take the place of one of the contestants. The participants include two college football players...

Four guys, one camera, and their experience chronicling the exhilarating and terrifying rite of passage: losing your virginity. As these guys help their buddy get laid, they'll have to survive friends with benefits, Internet hookups, even porn stars during an adventure that proves why you will always remember your first.